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Senior Thesis

Members of the Biology faculty pride themselves on being able to offer Villanova undergraduates the opportunity to be involved in meaningful biological research. We welcome all qualified students to consider including a research experience in their undergraduate curriculum.

Undergraduate research may be conducted over a single semester, or over more than a year. To get a taste of research, students may arrange with a faculty member to take Directed Research (Bio 6509), in which they complete a project lasting one semester. Any Biology major having a GPA of at least 3.0 can work toward a senior thesis (Bio 6609, 6610, 6709) that would involve at least two semesters of research for credit.

List of Recently Completed Senior Theses

Student Mentor Thesis Title
2008
Daniel Boland Knepper The effects of overexpression of the Tmem170 gene on mouse mammary tumor development
Erin Brault Wieder The effects of summertime rainfall exclusion on understory net CO2 exchange in two Western Canadian bogs
Laura Ceccacci Curry Does male parental behavior influence mate fidelity in the Carolina Chickadee, Poecile carolinensis
Kristin DiGregorio Russo A comparison of uterine proliferative effects of 17b-estradiol and the selective estrogen receptor modulators tamoxifen and roloxofene in the ovariectomized immature rat
Lauren Francis DiBenedetto Expression and mechanism of expression of brd2b maternal RNA in Danio rerio oocytes
J. Patrick Gorres Knepper Localization of the protein product of the predicted proto-oncogene GAV in NIH3T3 fibroblast cultures
Nathan Haag Russell Assessing tagging efficacy of calcein concentrations in the sea urchin Stronglocentrotus droebachiensis
Reeti Kumar M. K. Francis Skin cancer: identification of the relationship between PEDF, an angiogenic inhibitor, and blood vessel density
Andrew Mathew DiBenedetto Construction of His-tagged brd2 fusion genes for antigen production and testing for optimum expression in E. coli
Aishat Mohammed Wykoff Identification of mutants in the phosphate signal transduction pathway in Schizosaccharomyces pombe
Jane Pancurak Orkwiszewski Modifications of vegetative development in maize
Tatjana Prsa Vila and Weston Impact of rising sea levels and salinity intrusion on the metabolic activity and community composition of sulfate reducing bacteria in tidal freshwater marsh sediments
Janel Rodríguez DiBenedetto Patterns of expression of brd2a and brd2b in zebrafish spermatogenesis
Ashley Sjolund Rui (Jefferson) Analysis of breast cancer using cutting edge matrix assembly arrays
2007
Joseph Caruso Russo NF-KB, a key intermediate in inflammatory gene expression, is activated by estrogen in the immature rat uterus
Florian Dibra Desmond The kinetics of neuroepithelial growth at a critical time of brain development in the chick embryo
Catherine Kinrade Olson Effects of zinc and cadmium on development in the African clawed frog (Xenopus laevis)
James Geraghty Russell

A quantitative assessment of spermatozoa morphology in Nutricola confusa and Nutricola tantilla (Bivalvia: Veneridae)

Andrew McGann Curry Carolina Chickadee (Poecile carolinensis) winter flock behavior in southeastern Pennsylvania: observations from the winters of 2005-06 and 2006-07
Bryan Zimdahl M. K. Francis Identification of the TGF-b responsive region in the EPC-1 promoter: a wound healing model
2006
Elizabeth Gesel A. Francis A bilateral comparison of adductor mandibulae fiber composition in the winter flounder, Pseudopleuronectes americanus
Scot Niglio (Honors) Knepper Visualization of the GAV region of integration for mouse mammary tumor virus with fluorescent in situ hybridization
Chanelle Case Knepper RNAi inhibition of cathepsin L in mouse mammary tumor cells
Morgan Jones (Honors) Bamezai Ly-6A.2 mediated induction of a proliferative response in B cells
Lauren DiMenna Olson Development of immune function in Japanese Quail (Coturnix japonica): effects of an immunological challenge on hematology and the bursa of Fabricius
Daryl DiRocco Desmond Optic nerve flexing: mechanical stress and damage
Morgan Falk Webb Neuromast morphology and lateral line system development in two cichlids, Labeotrophus fuelleborni and Metriaclima zebra
Thomas Kennedy Jackman Molecular phylogenetics of Hemidactylus geckos from Southern India and Sri Lanka
2005
Christine Brooks (Honors) Bamezai The role of lipid rafts in the induction of growth inhibition in a cancer cell Line in response to antibodies against GPI-anchored proteins
Elissa Carney (Honors) Davis (Physics) & Dollahon Investigation of ferritin in mammalian iron metabolism
Trista Felty (Honors) Boulton Arthropod richness and abundance on Pennsylvania college campuses
Adrienne Laury (Honors) DiBenedetto The effect of SERMs on the spatial kinetic distribution of apoptosis in the model system of the immature rat uterus
Imran Punekar (Honors) Olson Ontogenetic and energetic consequences of an immunological challenge in Japanese Quail (Coturnix coturnix japonica)
Stephen Van Pelt (Honors) Curry Hybridization between the Carolina and Black-capped Chickadee: a further test of Haldane’s rule
Oleg Vishnevsky (Honors) Russo The role of inflammation in estrogen-induced matrix turnover and MMP regulation in the immature rat uterus
M. Nicholas Weber (Honors) Curry Determining the utility of longer microsatellite repeats in the molecular analysis of a local chickadee hybrid system
John Wenzel (Honors) Dollahon Investigation of parasites in Pennsylvania Canada Geese and their social/public implications
Chrissa Walsh Boulton Ecology of insular ant dominants in the Sea of Cortez
Beth Salonia Boulton Community ecology of a common North American wood ant, Formica subsericea
Amanda Smolock Russo Regulation of metalloproteinases in the ovariectomized rat uterus by 17β-estradiol
Crystal Kraft Knepper Expression of potential gene sequences in a mouse mammary tumor virus integration region
Elizabeth Spehalski Russo The regulation of mitogen-activated protein kinases by the selective estrogen receptor Raloxifene
Ryan Walsh Webb Ontogeny of the inner ear in the spotfin butterflyfish, Chaetodon ocellatus
Benny Johnson Jackman With- and between-species gene trees: phylogenetic analysis of New Caledonian geckos

How much research you complete is up to you, in consultation with your advisor and supervising faculty member—but the effort is virtually never wasted: few things can better help you stand out from your competitors when it comes time to apply for graduate school, professional programs, or employment. Until you try your hand at research, you can’t make an informed decision about pursuing (or ruling out) many career options.

How do I get started in research at Villanova?

  • Learn about the research activities of our faculty as soon as you can. Visit the faculty pages on this web site to gain a sense of what different members of the faculty do. Follow this up by going to see any faculty member whose work interests you: make an appointment, or just drop by during office hours. It never hurts to ask about opportunities that might exist!
  • Work part-time as a laboratory or field assistant during the regular school year, or over the summer. Ample opportunities exist for helping faculty and their graduate students in the tasks that are central to biological research, while earning hourly pay. Duties may include laboratory preparation, care of animals, preparation of specimens, computerized data entry, or collection of data or samples in the lab or field. Working in several different labs can expose you to a range of possibilities for independent study, while helping you get to know several different faculty with whom you might want to work. Some faculty members will suggest a project to get you started; others would prefer to see you develop a general interest in the work being done, from which ideas for a specific project can develop. Experience gained in this way at Villanova or elsewhere can develop into an independent research project.

One key to research success is to get involved as early as possible during your undergraduate career. Beginning senior thesis research in the fall of your Senior year might be OK for someone doing only library research, but scientific research in the laboratory or field usually involves unpredictability and therefore frustration and delays. The amount of time needed to complete a project often varies by biological subdisciplines. In molecular biology, for example, it may make sense to wait until you have taken advanced coursework before attempting a laboratory project. (Still, there’s much to be gained from prior exposure to the activities of a lab as an hourly worker assisting with the research.) Also, lab-based biology can usually be done throughout the year, including winter, so you can work throughout Senior year. In contrast, research in field biology (e.g., ecology or behavior) may require more advance planning, especially if a phenomenon of interest (e.g., breeding or germination) only occurs during the summer. It’s not uncommon for students doing ecological studies to begin working with a faculty member during their Sophomore year, with their major “push” for data collection taking place during the summer between their Junior and Senior year. The earlier you have data in hand, the more time you will have to complete a satisfying and scientifically valuable senior thesis.

The commitment of time and effort required for completing a senior thesis is probably going to be greater than you might think. Your senior thesis will involve extensive planning, data collection, analysis, and preparation of the thesis document (usually a report comprising 20 or more pages, along with figures and tables reporting your original results). Thus, a thesis is not worth doing unless you are able to make this a high priority during your Senior year (and, perhaps, the year before that). And yes, it does involve a lot more work than that required for the biology degree. Still, completing a thesis is without doubt worth the effort if done well. You have an opportunity at Villanova to gain research experience through work on a thesis that students at many schools are not given. Further, it will give you an opportunity to make a scientific contribution that will be significant in your applications to graduate and professional school. The Department of Biology would be happy to see more of its majors succeed in meeting this challenge.

Students completing the degree requirements for the Bachelor of Science, Honors Program (B.S.H.) are required to complete a Senior Thesis, but you do not have to be an Honors major to do research for a thesis; you just have to be an interested Biology major with a GPA over 3.0.

Research funding

Opportunities exist to obtain financial support for your research activity. In particular, the College of Liberal Arts & Sciences now has a generous program for Undergraduate Research Grants for summer work or for research during the school year. Students conducting research under the direction of Biology faculty mentors have had great success in this program. Additional possibilities exist for support from faculty research grants or from external student award programs. Contact your advisor or research mentor for more information.